Resume：

Position: Director of the Nephrology Department
Title: Chief Physician
Educational Background: Bachelor Degree

Main Disciplines:

Diagnosis and treatment of kidney diseases

Research Orientation:

Diagnosis and treatment of various renal diseases, treatment of severe renal failure, vascular access surgery and interventional treatment for hemodialysis patients, and tube grafting surgery for abdominal dialysis patients.

Scientific Research Achievements:

Head of the topic jointly funded by the Province and Ministry of Health “Effect of astragalus side on the expression of podocyte 31 integrin and integrin ligase in early stage of diabetic nephropathy” (WKJ2009-2-017). Zhejiang Provincial Nature Fund "New mechanism of LY12H05001 astragalus methyl side in the inhibition of podocytosis in early diabetic nephropathy", "Study on LY14H050004 inhibition of podocyte foot cell fusion in diabetic nephropathy through p130Cas" participants.

The articles published are as follows:

1.Chen J, Gui D, Chen Y,et al. Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via alpha3beta1 integrin upregulation and integrin-linked kinase inhibition[J]. Biochem Pharmacol. 2008 Sep 15;76(6):796-804.

2. Chen Jianguo, Gui Dingkun, Mou Lijun, et al. Protective effect and mechanism of astragalus on podocyte adhesion function under high glucose stimulation [J]. The Chinese Journal of Kidney Disease, 2009, 25(3): 227-232.

3.Gui D, Guo Y,  Chen J, et al. Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo[J]. PLoS One. 2012;7(6):e39824.

4.Gui D, Huang J, Chen J, et al.Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression[J]. Cytokine. 2013 Mar;61(3):970-7.

5. Luo Yunling, Chen Yifang, Chen Jianguo, et al. Effects and mechanism of astragalus methyl side on podocytes in rats with diabetic nephropathy [J]. Zhejiang Medicine, 2014 (7).

6.Chen J, Chen Y, Luo Y, et al. Astragaloside IV ameliorates diabetic nephropathy involving protection of podocytes in streptozotocin induced diabetic rats[J]. European journal of pharmacology, 2014, 736: 86-94.

7. Chen Y, Gui D, Chen J, et al. Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats[J]. Cell Physiol Biochem. 2014;33(6):1975-87.

Resume:

Graduated from The Medical School of Zhejiang University in 1986. He went to the CHARITE Medical Center of Humboldt University in Germany. He has participated in international academic exchanges in the United States, Europe, Japan and South Korea for many times.Currently, he is a member of Kidney Disease Branch of Zhejiang Medical Association, member of Provincial Dialysis Quality Control Center Committee, member of Zhejiang Branch of Chinese Dialysis Transplant Research Society, and member of Artificial Kidney Committee Branch of Zhejiang Biomedical Engineering Society.He has undertaken the bidding project of the key discipline group of geriatrics in Zhejiang Province and the research project jointly built by provinces and ministries. His works on basic research and clinical research of kidney disease were published in American and European SCI journals and domestic core professional journals respectively

Expert Outpatient Hours:

Outpatient Hours: Tuesday morning (Lingyin Hospital)

               Tuesday afternoon (Sandun Hospital)