In 1954, the Hospital was established. It was used to be called "Zhejiang Provincial Xishan Hospital" and "Zhejiang Provincial Hangzhou No. 2 Hospital" with 64 beds initially. 


In 1956, the Hospital was formally named "Zhejiang Hospital" and was clearly defined as a cadre healthcare hospital and a designated foreign-oriented hospital with 100 beds. Patients admitted to the Hospital mainly were middle and senior cadres (with the administrative level of 14 and above), foreign guests, overseas Chinese, and intellectuals with medium professional titles. 


In 1964, the Office of the Zhejiang Province People's Committee issued the Notice on Adjustment of Patients Admitted to Zhejiang Hospital, stipulating that patients to be admitted to the Hospital should be provincial-, prefectural-, and municipal-level government officials with the administrative level of 15 and above, directors/deputy directors of CPC prefectural and municipal committees, secretaries/deputy secretaries of CPC county committees, county mayors, division directors/deputy division directors of provincial-level government organs with the administrative level of 16, division directors of specialized and municipal-level government organs, professors/associate professors at junior colleges, chief engineers/deputy chief engineers at factories and mines, senior (and above) doctors and distinguished veteran doctors of traditional Chinese medicine at provincial-level hospitals and Hangzhou No. 1 Hospital.


In 1970, the Zhejiang Hospital Committee of the Communist Party of China was established. Between November 1970 and May 1971, the Hospital stopped to receive extrinsic patients as required by the Health Office of the Production Command Group of the Zhejiang Provincial Revolutionary Committee. Mogan Mountain Clinic was supervised by the Hospital and then by Mogan Mountain Administration Bureau in 1979.



In 1971, Zhejiang Provincial Revolutionary Committee released a document to adjust the range of patients admitted to the Hospital: 1. foreign guests, central leaders, and major comrades-in-charge from other provinces who needed to come to Hangzhou for treatment. 

In 1979, the Hospital was opened to the public with 190 beds. 


In 1981, Zhejiang Province Geriatrics Laboratory was established and affiliated to the Hospital. In 1993, the Laboratory was renamed Zhejiang Province Geriatrics Research Institute. 


In 1983, the Hospital established the No. 2 Building. As a result, it had 9 inpatient wards and 250 beds. From July 1983 to February 1984, Wangjiangshan Hospital run as the branch of the Hospital. The Hospital set up a clinic at the General Office of Zhejiang Provincial People's Congress. 


In 1984, the Hospital established a clinic at the People's Government of Zhejiang Province Building, Qingfeng Clinic, and Garden Clinic (healthcare stations). 


In 1986, Zhejiang Province Cardiovascular and Cerebrovascular Diseases Prevention and Treatment Office was established and affiliated to the Hospital. In 2005, the Office was renamed Zhejiang Province Cardiovascular and Cerebrovascular Diseases Prevention and Treatment Research Center.


In 1988, the Hospital established an intensive care unit (ICU), one of the earliest comprehensive ICUs in China. 


In 1989, the Hospital became the emergency sub-center of west Hangzhou. Zhejiang Province Medical Equipment Management and Maintenance Center was established and affiliated to the Hospital. In 2004, the Center was renamed Zhejiang Province Medical Equipment Management Quality Control Center. 


In 1991, the Hospital established the No. 3 Building. As a result, it had 12 inpatient wards and 400 beds. The manning quotas increased by 100. It became the teaching base of the Shanghai University of Traditional Chinese Medicine and Zhejiang College of TCM. Zhejiang Province Hospital Management Research Center was established and affiliated to the Hospital. 


In 1994, the Hospital became a teaching hospital of the Zhejiang University. 


In 1995, the Hospital was recognized as a Grade-III Class-A hospital by the Health Department of Zhejiang Province. 


In 1997, the Hospital became a teaching hospital of the Hangzhou Normal University School of Medicine. 


In 1999, the Cardiac Rehabilitation Center of the Hospital was established. 


In 2000, the Hospital became a training base for general practitioners in Zhejiang Province. 


In 2001, the Lung Cancer Clinic Center and Sleep-disordered Breathing Clinic Center of the Hospital were established. The Hospital became a teaching hospital of medical colleges and universities in Zhejiang Province. Zhejiang Province Cadre Healthcare Center and Prevention and Treatment of Cardio-Cerebral-Vascular Disease Periodical Office were established and affiliated to the Hospital. The Hospital was awarded Zhejiang Provincial Civilized Unit and Central Healthcare Excellent Collective. 


In 2002, the Hospital became the geriatrics prevention and treatment training base of Zhejiang Province. It established a partnership with the State University of New York. 


In 2003, the Cardiac Pacing Center of the Hospital was established. The Hospital was recognized as Excellent Collective in Fighting against SARS of National Committee of the Chinese Educational, Scientific, Cultural, Medical and Sports Workers' Union. 


In 2004, the Hospital established the No. 6 Building. As a result, it had 15 inpatient wards and 500 beds. It took over the Hangzhou Ninth People's Hospital to establish a branch of the Hospital. The Blood Purification Center of the Hospital was established. It set up the No. 70 Clinic. The Zhejiang Province Medical Device-Related Adverse Event Monitoring Center was established and affiliated to the Hospital. It was awarded the National Hospital Cultural Building Excellent Collective. 


In 2005, the Department of Cardiac Macrovascular Surgery was established. Zhejiang Hospital Branch Emergency Station of Hangzhou 120 First Aid Center was established. The Hospital became the State Drug Clinical Trial Institution and a collaborative hospital of the Fuwai Hospital of Chinese Academy of Medical Sciences. 


In 2006, the Hospital newly built a comprehensive outpatient building and a cadre healthcare center building. 


In 2007, the Hospital established Baoshiyuan Clinic and Zijin Yayuan Clinic. It set up the Mechanical Ventilation and Hemodynamic Test Clinical Training Center. 


In 2008, the ICU Quality Control Center in Zhejiang Province and Thoracic Cancers Research and Guidance Center of Zhejiang Province Cancer Center were established and affiliated to the Hospital. The Hospital became a training base of Arrhythmia Diagnosis and Treatment Technologies of the Ministry of Health. 


In 2009, the No. 1 Building was renovated and the No. 8 Building was newly built, increasing the number of inpatient wards to 18 (including the ones for physical examination). The manning quotas reached 860. The Osteoporosis Diagnosis and Treatment Center of the Hospital was established.


In 2011, Zhejiang Province Geriatric Medical Center broke ground, planning to build 1,000 beds. The Hospital established the Low Vision Rehabilitation Center, Clinic for Foreign Guests, and Geriatrics Multidisciplinary Team. The Hospital was recognized as the National Civilized Unit. 


In 2012, the No. 9 Building was renovated, increasing the number of inpatient wards to 21. The Hospital established the China-US Diabetes Center with the Indiana University Hospital. It built the Hypertension Center and Rehabilitation & Treatment Center. Partnerships with the Cardinal Tien Hospital and Deutsches Herzzentrum Berlin were established. The Hospital was awarded the National Health System Excellent Collective.

In 2013, the Hospital cooperated with the People's Government of Anji County and the People's Government of Pinghu County to establish the Anji Branch and Pinghu Branch of the Zhejiang Hospital. The Heart Center of the Hospital was set up. Zhejiang Province Geriatrics Diagnosis and Treatment Guidance Center was established and affiliated to the Hospital.

In 2015, the Kaihua Branch of the Zhejiang Hospital was established.

In 2015, the Hospital passed the review and kept the honorary title of National Civilized Unit; ICU was awarded the honorary title of National Role Model Women's Group; the official WeChat account of the Hospital was recognized as Top 100 Official WeChat Accounts of Hospitals in China; Yan Jing, Director of the Hospital, received the honorary title of 2015 National Excellent Worker.

In 2016, the No. 12 Building was newly built. The Hospital completed the task to support the G20 Hangzhou Summit. The Cardiac Intervention Center of North Zhejiang and Zhejiang Province Medical Equipment Management Center were set up. The Translational Medicine Center was established. The Hospital became the first medical institution in China to cooperate with BGI Genomics to build a genetic testing laboratory for geriatrics. In November, the Hospital Management Institute of the Fudan University issued the 2015 Ranking of Disciplines with the Best Reputation among Hospitals in China. Department of Critical Care Medicine and Department of Geriatrics were nominated.

In 2017, the Hospital led the construction of the Zhejiang Geriatric Specialized Union and Zhejiang Hospital High-Level Medical Treatment Partnership System. The Hospital operated the Xihu District Hospital of Chinese and Western Medicine in the mode of "operating inpatient wards and supporting outpatient service".

On June 28, 2018, Sandun Campus (Zhejiang Province Geriatric Medical Center) was put into operation. Zhejiang Hospital had two campuses from then on.

In 2019, the Jinhua Branch of the Zhejiang Hospital was established. Integrated Lung Cancer Center (iLCC), the first in Zhejiang Province, and iLCC Demonstration Inpatient Ward were established.